![]() ![]() ![]() They may also be prescribed for other disorders, such as panic disorder or obsessive-compulsive disorder ( OCD). These medications work by increasing the concentration of serotonin, an important neurotransmitter, throughout your brain and body.īoth medications are approved for use as treatments for depression. Prozac and Zoloft are both antidepressants of the selective serotonin reuptake inhibitor (SSRI) class. We’ve also listed side effects, drug interactions and other helpful information that you should be aware of before using either medication to treat depression, generalized anxiety disorder (GAD) or other mental health issues. Zoloft and Prozac are both generally effective, but there are several differences between the two antidepressant drugs that you should be aware of before you start treatment.īelow, we’ve talked about how Prozac and Zoloft work, as well as the main differences between these two medications. If you’ve recently been diagnosed with major depressive disorder or one of several other mental health conditions, your healthcare provider may suggest using Zoloft, Prozac or a similar type of antidepressant medication to control your symptoms. We’ve explained more about how SSRIs such as Zoloft and Prozac work in our complete guide to selective serotonin reuptake inhibitors (SSRIs). Both medications work by changing the level of serotonin - a neurotransmitter that’s linked to depression - that’s present in your brain. Prozac and Zoloft are both selective serotonin reuptake inhibitors, or SSRIs. Prozac®, which contains the active ingredient fluoxetine, and Zoloft®, which contains sertraline, are two of the most widely used antidepressants available today.
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